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Essentials Skin Cream

(0.3% Estriol)

An estriol-based prescription skin cream that plumps the skin, restores elasticity, shrinks pores, boosts collagen, & improves dryness and dullness.

Important Safety Information

All prescriptions require a consultation with a licensed provider, either asynchronously or synchronously. If the provider determines the medication isn’t appropriate for you, you’ll receive a full refund.... Read more

Hydrate & Revitalize

Deeply nourishes and moisturizes the skin, promoting a smooth and radiant complexion.

Anti-Aging

Combats fine lines, wrinkles, and dullness with ingredients that support collagen production.

Protect and Repair

Shields skin from environmental damage while promoting cellular repair.

Skin that keeps up with you

Estrogen-based prescription face cream curated specifically for perimenopausal and menopausal women.

  • Boosts collagen
  • Shrinks pores
  • Plumps the skin
  • Improves dullness
  • Restores elasticity
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“The Joi skincare line is fantastic! Their products are gentle and effective, and I have noticed a significant improvement in the appearance of my skin since using them.”

— Ashley Richards

Have questions? We’re here to help

We recommend using this cream just as you would a regular moisturizer, either in the morning or night after washing your face. One full pump daily will last you the length of the subscription.


Our skin creams do not contain photosensitive ingredients and can be applied at any time of day. If using in the morning, follow with SPF for added skin protection.


Yes, this skin cream can be integrated into your regular skincare routine. For optimal absorption, apply after serums and before moisturizer. Allow each product to fully absorb before layering additional skincare to maximize effectiveness.


Avoid contact with the eyes and mouth. While our skin creams can be applied to the throat, the skin in this area is more sensitive. Start with a small amount and monitor for irritation before applying more regularly.


At Joi+ Blokes, we take a holistic, preventative approach to care, which means many advanced treatments and lab tests are not typically covered by insurance. However, we do offer insurance-pay options for certain prescriptions:

  • Women’s health medications like estrogen and progesterone can be sent to your local pharmacy, where you may use your insurance benefits.
  • Thyroid medications will be sent to your local pharmacy, allowing you to utilize your insurance coverage.
  • FDA-approved GLP-1/GIP medications for weight loss and type 2 diabetes, including Ozempic, Wegovy, Zepbound, and Mounjaro, may also be eligible for coverage.

While we assist with prior authorizations and prescription submissions, we do not bill insurance directly. We recommend checking with your insurance provider for specific coverage details.


Yes! You can use your HSA or FSA funds to cover eligible purchases. We are happy to provide a detailed receipt and a Letter of Medical Necessity (LMN) from your provider. You can then submit these documents to your HSA/FSA account for potential reimbursement. Since coverage varies by plan, we recommend checking with your provider to confirm eligibility.


Email us at info@joiandblokes.com with any more questions.


Not sure where to start?

We recommend getting lab-tested first to give you access to a health coach and clinician that will help guide your personal health.

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Feel better, live longer

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The Journal

This Skin Care Routine Will Help You Beat Perimenopause Acne
March 27, 2025

This Skin Care Routine Will Help You Beat Perimenopause Acne